Trimming the Fat in HFpEF

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Trimming the fat, do we know where to begin?

T he worldwide prevalence of obese and overweight individuals has increased ≈3-fold during the past 30 years, from 857 million in 1980 to 2.1 billion in 2014. 1 Once thought to be a rich world problem, rates have increased dramatically even in low-and middle-income countries with 1 in 7 obese individuals residing in China and India. As global demographic trends continue to shift toward urbaniza...

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Breakthrough Concept in Hfpef

Heart failure with preserved ejection fraction (HFPEF), a clinical syndrome where heart failure (HF) exists in the presence of normal or near-normal left ventricular ejection fraction (LVEF), accounts for up to half of all HF patients. However, in contrast to heart failure with reduced ejection fraction (HFREF), where therapeutic advances have significantly improved outcomes over the last two d...

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Randomized Clinical Trials in HFpEF

Heart Failure With Preserved Ejection Fraction Heart failure with preserved ejection fraction (HFpEF) or diastolic heart failure (HF) accounts for approximately half of HF cases in the community, and the portion of HF with preserved ejection fraction (EF) is increasing. Patients with HFpEF have limited functional capacity and poor prognosis. With ongoing shifts in the age distribution of the po...

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The many faces of HFPEF: insights from the CMR substudy of DIAMOND-HFPEF

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ژورنال

عنوان ژورنال: JACC: Basic to Translational Science

سال: 2020

ISSN: 2452-302X

DOI: 10.1016/j.jacbts.2020.08.001